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Johnson Matthey is pleased to announce the addition of Trichickenfootphos (TCFP) to its chiral ligand offering.

TCFP offers a new dimension to the Johnson Matthey portfolio as it represents our first P-chiral ligand that is both small and highly electron rich.

This combination gives TCFP unique properties that allow it to perfom rhodium based catalysis on a range of prochiral substrates where more typical ligands fail.

The rhodium catalysts prepared from the ligand are excellent for the asymmetric reduction of:

• Enamides
• Ketones
• Unsaturated acids

The advantage of the small molecular weight and the very electron rich phosphines means excellent turnover numbers are achieved on a weight/weight basis and the stereochemical message of the P-chiral centre close to the metal allows very high asymmetric induction.

References: Hoge et al.,  Org. Lett. 2004; 3645-3647; Hoge et al.,  J. Am. Chem. Soc. 2004 5966-5967; Hoge et al., J. Am. Chem. Soc. 2008 2560-2572

Johnson Matthey has successfully scaled TCFP to multi-kilo production and it is now available through our global sales outlets.